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. 2005 Sep 15;250(2):195-200.
doi: 10.1016/j.femsle.2005.07.005.

Peptidoglycan precursor pools associated with MraY and FtsW deficiencies or antibiotic treatments

Beatriz Lara  1 , Dominique Mengin-Lecreulx, Juan A Ayala, Jean van Heijenoort
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Peptidoglycan precursor pools associated with MraY and FtsW deficiencies or antibiotic treatments

Beatriz Lara et al. FEMS Microbiol Lett. .

Abstract

Blocking peptidoglycan synthesis in Escherichia coli with moenomycin or vancomycin led to the accumulation of UDP-MurNAc-pentapeptide and of its immediate upstream precursors, whereas with cephaloridine or penicillin G the pool of UDP-MurNAc-pentapeptide decreased. With MraY and FtsW deficiencies the decrease of UDP-MurNAc-pentapeptide was accompanied by an increase of the upstream nucleotide precursors and the appearance of UDP-MurNAc-tetrapeptide.

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