doi: 10.1016/j.vaccine.2005.06.033.
Epub 2005 Jul 28.
Mucosal and systemic immunization elicited by Newcastle disease virus (NDV) transgenic plants as antigens
Affiliations
- PMID: 16099555
- DOI: 10.1016/j.vaccine.2005.06.033
Item in Clipboard
Mucosal and systemic immunization elicited by Newcastle disease virus (NDV) transgenic plants as antigens
Vaccine.
.
Abstract
As a step towards developing a safe and effective edible vaccine against Newcastle disease virus (NDV), we have explored the use of plants genetically engineered to express viral proteins. We report the construction of transgenic potato plants expressing the genes coding for immunogenic proteins of NDV under the regulation of CaMV 35S promoter and its immunogenicity in mice. All mice receiving transgenic plant extracts in incomplete Freund adjuvant produced specific anti-NDV antibodies. Animals fed with transgenic leaves showed a specific response against NDV. Detection of IgA released from in vitro-cultured intestinal tissue fragments indicated the presence of IgA-secreting cells in the gut.
Similar articles
-
Mucosal immunity induced by orally administered transgenic plants.Immunobiology. 2008;213(8):671-5. doi: 10.1016/j.imbio.2008.02.002. Epub 2008 Apr 2. Immunobiology. 2008. PMID: 18950595
-
Expression of the fusion glycoprotein of Newcastle disease virus in transgenic rice and its immunogenicity in mice.Vaccine. 2007 Jan 8;25(4):591-8. doi: 10.1016/j.vaccine.2006.08.016. Epub 2006 Aug 28. Vaccine. 2007. PMID: 17049688
-
[Expression and immunization testing of fusion protein of Newcastle disease virus in leaf tissue of transgenic rice].Yi Chuan Xue Bao. 2005 Dec;32(12):1305-11. Yi Chuan Xue Bao. 2005. PMID: 16459660 Chinese.
-
Recombinant Newcastle disease virus-vectored vaccines against human and animal infectious diseases.Future Microbiol. 2015;10(8):1307-23. doi: 10.2217/FMB.15.59. Epub 2015 Aug 3. Future Microbiol. 2015. PMID: 26234909 Review.
-
The Application of Newcastle Disease Virus (NDV): Vaccine Vectors and Tumor Therapy.Viruses. 2024 May 30;16(6):886. doi: 10.3390/v16060886. Viruses. 2024. PMID: 38932177 Free PMC article. Review.
Cited by
-
Virus-like particles (VLPs): A promising platform for combating against Newcastle disease virus.Vaccine X. 2024 Jan 14;16:100440. doi: 10.1016/j.jvacx.2024.100440. eCollection 2024 Jan. Vaccine X. 2024. PMID: 38283623 Free PMC article. Review.
-
Development of Plant-Based Vaccines for Prevention of Avian Influenza and Newcastle Disease in Poultry.Vaccines (Basel). 2022 Mar 19;10(3):478. doi: 10.3390/vaccines10030478. Vaccines (Basel). 2022. PMID: 35335110 Free PMC article. Review.
-
Plant-Derived Recombinant Vaccines against Zoonotic Viruses.Life (Basel). 2022 Jan 21;12(2):156. doi: 10.3390/life12020156. Life (Basel). 2022. PMID: 35207444 Free PMC article. Review.
-
Potential use of the hemagglutinin-neuraminidase glycoprotein of Newcastle disease virus expressed in Rachiplusia nu larvae as an immunogen for chickens.Clin Vaccine Immunol. 2009 May;16(5):775-8. doi: 10.1128/CVI.00432-08. Epub 2009 Mar 18. Clin Vaccine Immunol. 2009. PMID: 19297615 Free PMC article.
-
Production of vaccines and therapeutic antibodies for veterinary applications in transgenic plants: an overview.Transgenic Res. 2007 Jun;16(3):315-32. doi: 10.1007/s11248-007-9095-x. Epub 2007 Apr 14. Transgenic Res. 2007. PMID: 17436059 Free PMC article. Review.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Research Materials
Miscellaneous
