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Review
. 2005 Aug;4(4):405-19.
doi: 10.2174/1568007054546072.

Neurodegenerative pathways in Parkinson's disease: therapeutic strategies

S M Cardoso  1 , P I Moreira, P Agostinho, C Pereira, C R Oliveira
Affiliations
Review

Neurodegenerative pathways in Parkinson's disease: therapeutic strategies

S M Cardoso et al. Curr Drug Targets CNS Neurol Disord. 2005 Aug.

Abstract

Parkinson's disease (PD), considered one of the major neurological disorders, is characterized by the loss of dopaminergic neurons in the pars compacta of the substantia nigra and by the presence of intraneuronal cytoplasmic inclusions called Lewy bodies. The causes for degeneration of PD neurons remain unclear, however, recent findings contributed to clarify this issue. This review will discuss the current understanding of the mechanisms underlying Parkinson's disease pathogenesis, focusing on the current and potential therapeutic strategies for human treatment.

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