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. 1992;66(5):365-7.
doi: 10.1007/BF01973633.

Activity of glutathione-S-transferase in rat liver and kidneys after administration of lead or cadmium

F Planas-Bohne  1 , M Elizalde
Affiliations

Activity of glutathione-S-transferase in rat liver and kidneys after administration of lead or cadmium

F Planas-Bohne et al. Arch Toxicol. 1992.

Abstract

The influence of an acute dose of lead nitrate or cadmium chloride on the activity of glutathione-S-transferase (GST) was investigated in rats. CdCl2 (10 mumol/kg) did not influence the enzyme activity in either organ. In contrast Pb(NO3)2 (100 mumol/kg) caused a significant increase of GST activity in both organs. SDS polyacrylamide gel electrophoresis (SDS-PAGE) showed that in liver the activity enhancement is due mainly to the induction of the isoenzyme GST 7-7, while in the kidneys the activity of all the isoenzymes is increased.

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