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Review
. 2005 Aug;7(8):471-6.
doi: 10.1111/j.1524-6175.2005.04617.x.

Hypertension and the cardiometabolic syndrome

Camila Manrique  1 , Guido Lastra, Adam Whaley-Connell, James R Sowers
Affiliations
Review

Hypertension and the cardiometabolic syndrome

Camila Manrique et al. J Clin Hypertens (Greenwich). 2005 Aug.

Abstract

Hypertension and cardiovascular disease are leading causes of morbidity and mortality. Accumulating data demonstrate a relationship between hypertension and several vascular and metabolic abnormalities that are components of the cardiometabolic syndrome. The components of the cardiometabolic syndrome include insulin resistance/hyperinsulinemia, central obesity, dyslipidemia, hypertension, microalbuminuria, increased inflammation, and oxidative stress. There is growing evidence that tissue activation of the renin-angiotensin-aldosterone system participates in endothelial dysfunction, microalbuminuria, insulin resistance, and subsequent cardiovascular and chronic kidney disease. The notion that hypertension is a metabolic as well as a vascular disease opens a new paradigm for the treatment of this disorder.

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Figures

Figure
Figure
Systemic effects of angiotensin II. +=increased; −=decreased; VSMC=vascular smooth muscle cell; PAI‐1=plasminogen activator inhibitor type 1; AT1=angiotensin II type 1
See this image and copyright information in PMC

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