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. 2005 Sep 7;3(17):3188-93.
doi: 10.1039/b505881c. Epub 2005 Jul 27.

Wang-aldehyde resin as a recyclable support for the synthesis of alpha,alpha-disubstituted amino acid derivatives

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Wang-aldehyde resin as a recyclable support for the synthesis of alpha,alpha-disubstituted amino acid derivatives

Meritxell Guinó et al. Org Biomol Chem. .

Abstract

Merrifield resin was functionalised with hydroxybenzaldehyde under microwave irradiation. The resultant resin was used as a means for immobilisation and activation of alpha-amino acid esters for alkylation reactions. Alpha,alpha-disubstituted and cyclic amino acid esters were prepared in good yields.

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