Wang-aldehyde resin as a recyclable support for the synthesis of alpha,alpha-disubstituted amino acid derivatives
- PMID: 16106300
- DOI: 10.1039/b505881c
Wang-aldehyde resin as a recyclable support for the synthesis of alpha,alpha-disubstituted amino acid derivatives
Abstract
Merrifield resin was functionalised with hydroxybenzaldehyde under microwave irradiation. The resultant resin was used as a means for immobilisation and activation of alpha-amino acid esters for alkylation reactions. Alpha,alpha-disubstituted and cyclic amino acid esters were prepared in good yields.
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