Formation of novel secondary metabolites by bacterial multimodular assembly lines: deviations from textbook biosynthetic logic

Abstract

Microorganisms produce an immense variety of natural products with useful biological activities. These compounds are often biosynthesized by multifunctional megasynthetases known as polyketide synthases and nonribosomal peptide synthetases. Recent literature on these natural product assembly lines suggests that they have a much greater mechanistic diversity than originally anticipated.