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. 2005 Sep;36(9):2012-4.
doi: 10.1161/01.STR.0000177881.34840.cf. Epub 2005 Aug 18.

Ischemic stroke subtypes and thrombophilia in young and elderly Brazilian stroke patients admitted to a rehabilitation hospital

Francisco Javier Carod-Artal  1 , Simone Vilela Nunes, Dalton Portugal, Tania Virginia Fernandes Silva, Antonio Pedro Vargas
Affiliations

Ischemic stroke subtypes and thrombophilia in young and elderly Brazilian stroke patients admitted to a rehabilitation hospital

Francisco Javier Carod-Artal et al. Stroke. 2005 Sep.

Abstract

Background and purpose: We sought to examine ischemic stroke subtypes and prevalence of thrombophilia in Brazilian stroke patients.

Method: A total of 130 consecutive young and 200 elderly stroke patients were studied.

Results: Prevalence of thrombophilia was, respectively: protein S deficiency (11.5% versus 5.5%), protein C deficiency (0.76% versus 1%), resistance to activated protein C (2.3% versus 3.5%), mutation in V Leiden factor (1.5% versus 2%), antithrombin III deficiency (0% versus 0%), lupus anticoagulant (0% versus 0.5%), anticardiolipin antibodies (3% versus 10%; P=0.01), hyperhomocysteinemia (31.5% versus 53.5%; P=0.0001), mutation of the MTHFR gene in homocigosis (10% versus 5%), and heterocigosis (27.6% versus 41.9%; P=0.01).

Conclusions: Prothrombotic conditions were more frequent in stroke of undetermined cause.

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