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Review
. 2005 Oct;7(5):275-87.
doi: 10.1016/j.jfms.2004.12.005. Epub 2005 Apr 26.

Multiple myelomas in cats

Fikry Hanna  1
Affiliations
Review

Multiple myelomas in cats

Fikry Hanna. J Feline Med Surg. 2005 Oct.

Abstract

Multiple myelomas are uncommon neoplasms of the bone marrow of cats [Weber NA, Tebeau CS (1998) An unusual presentation of multiple myeloma in two cats. Journal of the American Animal Hospital Association34 (6), 477-483]. Nine cats diagnosed with multiple myelomas were retrospectively identified over a 16-year period (1986-2002). Cats with multiple myelomas were older than 7 years (mean age 11.7 years); six males and three females were affected (2.1), but no breed predisposition was evident. Treatment of multiple myelomas consisted of supportive management in the nine cats and anti-neoplastic therapy in eight cats. Supportive treatment consisted of maintaining hydration, renal function and antimicrobial therapy even when there was no sign of infection. Anti-neoplastic therapy with melphalan and prednisolone was carried out in eight cats. Three failed to respond to treatment and five responded to treatment, but the response was only partial and temporary in one cat. The five cats that responded were improved clinically and had reduced serum protein levels. Five out of eight cats (63%) responded to chemotherapy, and it appeared to be complete in four cats and partial in one cat. Survival time in those cats was 15, 4, 17 and 24 months.

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Figures

Fig 1
Fig 1
Case 8, serum protein electrophoresis. Note the narrow monoclonal spike in the gamma region.
Fig 2
Fig 2
Lateral radiograph of the left stifle, showing multiple focal lucencies at the left stifle and oblique fracture through the diseased bone in the proximal tibia.
Fig 3
Fig 3
Lateral radiograph of the left and right stifles showing multiple focal lucencies at the left and right stifles.
Fig 4
Fig 4
(A and B) Lateral and ventrodorsal contrast myelogram of the lumbosacral spine showing interruption of dye columns over L6/L7 vertebrae.
Fig 5
Fig 5
Case 2, histological section of bone marrow showing extradural infiltration of cells in the ventral aspect of the cord, these cells were medium sized oval cells with eccentric oval nuclei having the appearance of plasma cell neoplasia.
See this image and copyright information in PMC

References

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