Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2005 Sep;101(3):807-811.
doi: 10.1213/01.ane.0000166980.45162.1c.

The antinociceptive effect of local or systemic parecoxib combined with lidocaine/clonidine intravenous regional analgesia for complex regional pain syndrome type I in the arm

Luiz-Cleber P Frade  1 , Gabriela R Lauretti, Izabel C P R Lima, Newton L Pereira
Affiliations

The antinociceptive effect of local or systemic parecoxib combined with lidocaine/clonidine intravenous regional analgesia for complex regional pain syndrome type I in the arm

Luiz-Cleber P Frade et al. Anesth Analg. 2005 Sep.

Abstract

We evaluated the efficacy of local or systemic parecoxib combined with lidocaine/clonidine IV regional analgesia in complex regional pain syndrome (CRPS) type 1 in a dominant upper limb. Thirty patients with CRPS type 1 were divided into three groups. The control group (CG) received both IV saline in the healthy limb and IV loco-regional 1 mg/kg of lidocaine + 30 mug of clonidine, diluted to a 10-mL volume with saline. The systemic parecoxib group (SPG) received a regional block similar to that administered to the CG but with systemic 20 mg of parecoxib, whereas the IV regional anesthesia with parecoxib group (IVRAPG) received an extra IV 5 mg of loco-regional parecoxib compared with the CG. The block was performed once a week for 3 consecutive weeks. Analgesia was evaluated by the 10-cm visual analog scale (VAS) and rescue analgesic consumption. The IVRAPG showed less daily ketoprofen (milligrams) consumption in the second and third weeks compared with the other groups (P < 0.05). The IVRAPG also showed less ketoprofen consumption when comparing the first and second week with the third week (P < 0.05). The VAS score comparison among groups revealed that groups were similar during the first and second week observation, although the IVRAPG showed smaller VAS scores in the third week compared with both CG and SPG (P < 0.05). We conclude the IV 5 mg of parecoxib was an effective antiinflammatory drug combined with clonidine/lidocaine loco-regional block in CRPS type 1.

PubMed Disclaimer

References

    1. Lake AP. Intravenous regional sympathetic block: past, present and future? Pain Res Manag 2004;9:35–7.
    1. Vanos DN, Ramamurthy S, Hoffman J. Intravenous regional block using ketorolac: preliminary results in the treatment of reflex sympathetic dystrophy. Anesth Analg 1992;74:139–41.
    1. Gintautas J, Housny W, Kraynack BJ. Successful treatment of reflex sympathetic dystrophy by bier block with lidocaine and clonidine. Proc West Pharmacol Soc 1999;42:101.
    1. di Vadi PP, Brill S, Jack T, et al.. Intravenous regional blocks with guanethidine and prilocaine combined with physiotherapy: two children with complex regional pain syndrome, type 1. Eur J Anaesthesiol 2002;19:384–6.
    1. Hord ED, Stojanovic MP, Vallejo R, et al.. Multiple Bier blocks with labetalol for complex regional pain syndrome refractory to other treatments. J Pain Symptom Manage 2003;25:299–302.

MeSH terms

LinkOut - more resources