Patterns of autobiographical memory loss in dementia

Abstract

Background: Several studies have found impaired recall of remote autobiographical memories relative to recent memories in semantic dementia (SD), a pattern opposite to that in Alzheimer's disease (AD).

Objective: To document dissociation of memory for autobiographical incidents and personal semantic information in individuals with AD, frontotemporal dementia (FTD), and SD.

Methods: The authors administered the Autobiographical Memory Interview to eight individuals with AD, 11 with FTD, eight with SD, and eight normal controls . Autobiographical incidents and personal semantic memory was assessed from three time periods: childhood, early adulthood, and recent life.

Results: Individuals with SD recalled more details of autobiographical incidents from the most recent 5 years than from childhood and early adulthood (childhood vs recent life: t(7) = -3.59, p = 0.009; early adulthood vs recent life: t(7) = -4.33, p = 0.003). No difference was found between childhood and early adulthood (t(7) = 1.11, p = 0.305). Recall of personal semantic information was related to the age of the memory with less remembered from earlier time periods (childhood vs recent life: t(7) = -6.52, p < 0.001; childhood vs early adulthood: t(7) = -2.61, p = 0.035; early adulthood vs recent life: t(7) = -9.15, p < 0.001).

Conclusions: SD is a compelling model in which to study the anatomy of episodic memory.