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. 2005 Sep;20(9):859-61.
doi: 10.1111/j.1525-1497.2005.0181.x.

Brief report: Free prostate-specific antigen test utilization. Consistency with guidelines

Brian R Jackson  1 , William L Roberts
Affiliations

Brief report: Free prostate-specific antigen test utilization. Consistency with guidelines

Brian R Jackson et al. J Gen Intern Med. 2005 Sep.

Abstract

Background: The American Cancer Society and American Urologic Association recommend prostate cancer screening for average-risk men between the ages of 50 and 75 years using digital rectal examination and prostate-specific antigen (PSA) testing. Measuring the percent free PSA may improve test specificity for detecting prostate cancer when the total PSA is between 2.5 and 10 ng/mL.

Objective: To assess whether free PSA testing practices are consistent with published screening guidelines.

Design: Retrospective analysis of free PSA testing performed by a national reference laboratory between October 1, 2003 and September 30, 2004.

Measurements: Free PSA and total PSA results and the age of the patient at testing.

Results: Over 24% of free PSA tests were performed on patients greater than 75 years of age, and 38% were performed on patients with a total PSA either less than 2.5 ng/mL or greater than 10.0 ng/mL.

Conclusions: A substantial proportion of free PSA tests performed in a national reference laboratory appeared to be inconsistent with existing screening guidelines. This raises concern that some of these patients may have received inappropriate diagnostic workup and/or therapy, resulting in excess medical costs and potential harms.

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References

    1. Sirovich BE, Schwartz LM, Woloshin S. Screening men for prostate and colorectal cancer in the United States: does practice reflect the evidence? JAMA. 2003;289:1414–20. - PubMed
    1. Ross LE, Coates RJ, Breen N, Uhler RJ, Potosky AL, Blackman D. Prostate-specific antigen test use reported in the 2000 National Health Interview Survey. Prev Med. 2004;38:732–44. - PubMed
    1. Smith RA, von Eschenbach AC, Wender R, et al. American Cancer Society guidelines for the early detection of cancer: update of early detection guidelines for prostate, colorectal, and endometrial cancers. CA Cancer J Clin. 2001;51:38–75. - PubMed
    1. Carroll P, Coley C, McLeod D, et al. Prostate-specific antigen best practice policy—part I: early detection and diagnosis of prostate cancer. Urology. 2001;57:217–24. - PubMed
    1. Catalona WJ, Partin AW, Slawin KM, et al. Use of the percentage of free prostate-specific antigen to enhance differentiation of prostate cancer from benign prostatic disease. JAMA. 1998;279:1542–7. - PubMed

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