[Carcinosarcoma of the pancreas--case report and literature review]

Abstract

Forty seven year old man underwent laparotomy because of obstructive jaundice. As a cause of biliary tree obstruction a tumor of the head of the pancreas was diagnosed. Pancreatoduodenectomy was performed. Within removed specimen by histologic examination a malignant tumor with adenocarcinoma and leyosarcoma parts was diagnosed. Mesenchymal component immunohistochemically were strongly and diffusely reactive for antibodies to vimentin and actin, weak and focal for EMA. There was no reactivity to cytokeratin. Opposite, the epithelial component of the tumor revealed strong reaction to cytokeratin and EMA, but weak to vimentin and actin. To our knowledge it is twelfth case of carcinosarcoma of the pancreas confirmed immunohistochemically in the literature.