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Multicenter Study
. 2005 Sep;60(3):326-9.
doi: 10.1111/j.1365-2125.2005.02428.x.

Potential for drug interactions involving cytochrome P450 in patients attending palliative day care centres: a multicentre audit

A Wilcock  1 , J Thomas, J Frisby, M Webster, V Keeley, G Finn, K Fossey, B Wee, J Beale, M S Lennard
Affiliations
Multicenter Study

Potential for drug interactions involving cytochrome P450 in patients attending palliative day care centres: a multicentre audit

A Wilcock et al. Br J Clin Pharmacol. 2005 Sep.

Abstract

Aim: To determine the potential for drug interactions involving cytochrome P450 (CYP) in patients receiving palliative day care.

Methods: Drugs used by patients attending four specialist palliative day care centres were reviewed to identify combinations that could result in a pharmacokinetic interaction via any of the five main human forms of CYP.

Results: Of 160 patients, 145 (91%) were prescribed at least one drug that was a substrate, inhibitor or inducer of one of the five main CYP isoforms. Twenty-four drug combinations, involving 34 patients, could have given rise to a clinically important interaction.

Conclusions: Prescribers should be aware that in this group of patients, one in five are at risk of a clinically important CYP-mediated drug interaction.

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References

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