Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2004 Sep;4(5-6):755-62.
doi: 10.1016/j.mito.2004.07.027. Epub 2004 Oct 1.

Mitochondrial dysfunction in cancer

Josephine S Modica-Napolitano  1 , Keshav K Singh
Affiliations

Mitochondrial dysfunction in cancer

Josephine S Modica-Napolitano et al. Mitochondrion. 2004 Sep.

Abstract

Nearly a century of scientific research has revealed a number of notable differences in the structure and function of mitochondria between normal and cancer cells, including differences in metabolic activity, molecular composition, and mtDNA sequence. This article reviews several of these differences and discusses their clinical implications, especially with regard to the use of mitochondria as biomarkers for early detection of cancer, or as unique cellular targets for novel and selective anti-cancer agents.

PubMed Disclaimer

LinkOut - more resources