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Case Reports
. 2005 Aug;27(4):314-8.
doi: 10.1097/01.dad.0000171600.17692.65.

Combined high-grade basal cell carcinoma and malignant melanoma of the skin ("malignant basomelanocytic tumor"): report of two cases and review of the literature

Jaime Rodriguez  1 , Daisuke Nonaka, Elisabetta Kuhn, Martin Reichel, Juan Rosai
Affiliations
Case Reports

Combined high-grade basal cell carcinoma and malignant melanoma of the skin ("malignant basomelanocytic tumor"): report of two cases and review of the literature

Jaime Rodriguez et al. Am J Dermatopathol. 2005 Aug.

Abstract

We describe two cases of a malignant cutaneous neoplasm with combined phenotypical features of high-grade basal cell carcinoma and malignant melanoma. Some tumor cells showed a keratinocytic phenotype (cytokeratins, p63) and others a melanocytic phenotype (HMB-45, MART-1, Melan-A, S100-protein). We favor the hypothesis of a tumor with bidirectional keratinocytic and melanocytic differentiation, an exceptionally rare event.

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