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Review
. 2005 Dec 9;338(1):102-10.
doi: 10.1016/j.bbrc.2005.08.013. Epub 2005 Aug 11.

Regulation of 5-lipoxygenase enzyme activity

Olof Rådmark  1 , Bengt Samuelsson
Affiliations
Review

Regulation of 5-lipoxygenase enzyme activity

Olof Rådmark et al. Biochem Biophys Res Commun. .

Abstract

In this article, regulation of human 5-lipoxygenase enzyme activity is reviewed. First, structural properties and enzyme activities are described. This is followed by the activating factors: Ca2+, membranes, ATP, and lipid hydroperoxide. Also, studies on phosphorylation of 5-lipoxygenase and nuclear localization sequences are reviewed.

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