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. 2005 Aug 26;309(5739):1373-6.
doi: 10.1126/science.1115964.

Spatial coordination of spindle assembly by chromosome-mediated signaling gradients

Maïwen Caudron  1 , Gertrude Bunt, Philippe Bastiaens, Eric Karsenti
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Free article

Spatial coordination of spindle assembly by chromosome-mediated signaling gradients

Maïwen Caudron et al. Science. .
Free article

Abstract

During cell division, chromosomes are distributed to daughter cells by the mitotic spindle. This system requires spatial cues to reproducibly self-organize. We report that such cues are provided by chromosome-mediated interaction gradients between the small guanosine triphosphatase (GTPase) Ran and importin-beta. This produces activity gradients that determine the spatial distribution of microtubule nucleation and stabilization around chromosomes and that are essential for the self-organization of microtubules into a bipolar spindle.

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