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. 2005 Aug;68(8):1253-5.
doi: 10.1021/np0402221.

Antineoplastic agents. 542. Isolation and structure of sesterstatin 6 from the Indian Ocean sponge Hyrtios erecta

George R Pettit  1 , Rui Tan, Zbigniew A Cichacz
Affiliations

Antineoplastic agents. 542. Isolation and structure of sesterstatin 6 from the Indian Ocean sponge Hyrtios erecta

George R Pettit et al. J Nat Prod. 2005 Aug.

Abstract

A new scalarane-type pentacyclic sesterterpene, sesterstatin 6 (6), was isolated in 8.3 x 10(-7)% yield from the Republic of Maldives marine sponge Hyrtios erecta. The structure was elucidated by analyses of HRMS and high-field 2-D NMR spectra. Sesterstatin 6 showed significant cancer cell growth inhibition against murine P388 lymphocytic leukemia and a series of human tumor cell lines (ED50 0.17 microg/mL, GI50 1.8-8.9 x 10(-1) microg/mL) and proved to be the most inhibitory of the series.

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Figures

Figure 1
Figure 1
Key ROESY correlations of sesterstatin 6 (6).
None
See this image and copyright information in PMC

References

    1. Contribution 542 in the series Antineoplastic Agents: for part 541 refer to: Pettit GR, Tan R. J Nat Prod. 2005;68:60–63.

    1. Utkina NK, Denisenko VA, Scholokova OV, Virovaya MV, Prokof’eva NG. Tetrahedron Lett. 2003;44:101–102.
    2. Carletti I, Long C, Funel C, Amade P. J Nat Prod. 2003;66:25–29. - PubMed
    3. Liu Y, Hong J, Lee CO, Im KS, Kim ND, Choi JS, Jung JH. J Nat Prod. 2002;65:1307–1314. - PubMed
    4. Iwashima M, Terada I, Iguchi K, Yamori T. Chem Pharm Bull. 2002;50:1286–1289. - PubMed
    5. Charan RD, McKee TC, Boyd MR. J Nat Prod. 2002;65:492–495. - PubMed
    6. Paul GK, Gunasekera SP, Longley RE, Pomponi SA. J Nat Prod. 2002;65:59–61. - PubMed
    7. Youssef DTA, Yamaki RK, Kelly M, Scheuer PJ. J Nat Prod. 2002;65:2–6. - PubMed
    1. Pettit GR, Cichacz ZA, Tan R, Hoard MS, Melody N, Pettit RK. J Nat Prod. 1998;61:13–16. - PubMed
    2. Pettit GR, Cichacz ZA, Tan R, Herald DL, Melody N, Hoard MS, Doubek DL, Hooper JNA. Collect Czech Chem Commun. 1998;63:1671–1677.
    1. Pettit GR, Tan R, Melody N, Cichacz ZA, Herald DL, Hoard MS, Pettit RK, Chapuis JC. Bioorg Med Chem Lett. 1998;8:2093–2098. - PubMed
    1. Miyaoka H, Nishijima S, Mitome H, Yamada Y. J Nat Prod. 2000;63:1369–1372. - PubMed
    2. Yan Q, Deng Z, Pei Y, Fu H, Li J, Proksch P, Lin W. J Nat Prod. 2004;67:921–924. - PubMed

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