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Clinical Trial
. 2005 Aug;147(2):197-201.
doi: 10.1016/j.jpeds.2005.05.015.

The use of Lactobacillus GG in irritable bowel syndrome in children: a double-blind randomized control trial

Melissa Bauserman  1 , Sonia Michail
Affiliations
Clinical Trial

The use of Lactobacillus GG in irritable bowel syndrome in children: a double-blind randomized control trial

Melissa Bauserman et al. J Pediatr. 2005 Aug.

Erratum in

  • J Pediatr. 2014 Oct;165(4):878. Bausserman, Melissa [corrected to Bauserman, Melissa]

Abstract

Objective: To determine whether oral administration of the probiotic Lactobacillus GG under randomized, double-blinded, placebo-controlled conditions would improve symptoms of irritable bowel syndrome (IBS) in children.

Study design: Fifty children fulfilling the Rome II criteria for IBS were given Lactobacillus GG or placebo for 6 weeks. Response to therapy was recorded and collected on a weekly basis using the Gastrointestinal Symptom Rating Scale (GSRS).

Results: Lactobacillus GG was not superior to placebo in relieving abdominal pain (40.0% response rate in the placebo group vs 44.0% in the Lactobacillus GG group; P=.774). There was no difference in the other gastrointestinal symptoms, except for a lower incidence of perceived abdominal distention (P=.02 favoring Lactobacillus GG).

Conclusions: Lactobacillus GG was not superior to placebo in the treatment of abdominal pain in children with IBS but may help relieve such symptoms as perceived abdominal distention.

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