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Case Reports
. 2005 Sep;58(9):981-3.
doi: 10.1136/jcp.2004.022947.

ALK positive inflammatory myofibroblastic tumour of the pineal region

A J Clarke  1 , T S Jacques, M J Galloway, M Thom, N D Kitchen, G T Plant
Affiliations
Case Reports

ALK positive inflammatory myofibroblastic tumour of the pineal region

A J Clarke et al. J Clin Pathol. 2005 Sep.

Abstract

Inflammatory myofibroblastic tumours (IMTs) are an uncommon spindle cell neoplasm with a dense inflammatory infiltrate, usually encountered in children. IMTs of the central nervous system are extremely rare. This report describes the case of an IMT in a 61 year old man, in the pineal region. The tumour was completely excised, and immunohistochemistry demonstrated anaplastic lymphoma kinase 1 expression. There was no tumour recurrence during 18 months of follow-up. Our case extends both the age range and sites of occurrence of this rare tumour.

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Figures

Figure 1
Figure 1
Coronal T1 weighted magnetic resonance images (A) before and (B) after contrast with gadolinium showing an enhancing 2 cm tumour in the third ventricle in the region of the pineal gland, with mild hydrocephalus.
Figure 2
Figure 2
(A, B) Histology showed regions composed of elongated fibroblast-like spindle cells, mixed with (A, D) dense lymphocyte and plasma cell infiltrates. (C) There were intervening areas with large histiocytic cells with granular cytoplasm. The spindle cells showed positive immunostaining for (E) anaplastic lymphoma kinase 1 and (F) desmin.
See this image and copyright information in PMC

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References

    1. Umiker WO, Iverson L. Postinflammatory ‘tumour’ of the lung. Report of four cases simulating xanthoma, fibroma or plasma cell granuloma. J Thorac Cardiovasc Surg 1954;28:55–63. - PubMed
    1. Griffin CA, Hawkins AL, Dvorak C, et al. Recurrent involvement of 2p23 in inflammatory myofibroblastic tumours. Cancer Res 1999;59:2776–80. - PubMed
    1. Pulford K, Wade Morris S, York Mason D. Anaplastic lymphoma kinase proteins and malignancy. Curr Opin Hematol 2001;81:231–6. - PubMed
    1. Ten Berge RL, Oudejans JJ, Ossenkoppele GJ, et al. ALK expression in extranodal anaplastic large cell lymphoma favors systemic disease with (primary) nodal involvement and a good prognosis and occurs before dissemination. J Clin Pathol 2000;53:445–50. - PMC - PubMed
    1. Coffin CM, Patel A, Perkins S, et al. ALK1 and p80 expression and chromosomal rearrangements involving 2p23 in inflammatory myofibroblastic tumor. Mod Pathol 2001;14:569–75. - PubMed

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