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. 2005 Sep;49(9):3919-21.
doi: 10.1128/AAC.49.9.3919-3921.2005.

Mutations associated with sulfadoxine-pyrimethamine and chlorproguanil resistance in Plasmodium falciparum isolates from Blantyre, Malawi

Alisa P Alker  1 , Victor Mwapasa, Anne Purfield, Stephen J Rogerson, Malcolm E Molyneux, Deborah D Kamwendo, Eyob Tadesse, Ebbie Chaluluka, Steven R Meshnick
Affiliations

Mutations associated with sulfadoxine-pyrimethamine and chlorproguanil resistance in Plasmodium falciparum isolates from Blantyre, Malawi

Alisa P Alker et al. Antimicrob Agents Chemother. 2005 Sep.

Abstract

We conducted a prevalence study of mutations in Plasmodium falciparum that are associated with antifolate resistance in Blantyre, Malawi. The dihydrofolate reductase 164-Leu mutation, which confers resistance to both pyrimethamine and chlorproguanil, was found in 4.7% of the samples. Previously unreported mutations in dihydropteroate synthase were also found.

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Figures

FIG. 1.
FIG. 1.
The prevalence of mutant (black) and mixed (gray) genotypes in samples from pregnant women with malaria in Blanytre, Malawi. A mutant genotype is defined as encoding DHFR-51-Ile, DHFR-59-Arg, DHFR-108-Asn/Thr, DHFR-164-Leu, DHPS-437-Gly, DHPS-540-Glu, DHPS-581-Gly, and DHPS-613-Ser/Thr. The sample size is 89 for all codons except for the DHFR-59 (n = 90), DHPS-437 (n = 90), and DHFR-164 (n = 85) codons.
See this image and copyright information in PMC

References

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