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. 2005 Sep 7;127(35):12230-1.
doi: 10.1021/ja053079m.

Synthesis of spiro[4.5]trienones by intramolecular ipso-halocyclization of 4-(p-methoxyaryl)-1-alkynes

Xiaoxia Zhang  1 , Richard C Larock
Affiliations

Synthesis of spiro[4.5]trienones by intramolecular ipso-halocyclization of 4-(p-methoxyaryl)-1-alkynes

Xiaoxia Zhang et al. J Am Chem Soc. .

Abstract

A wide variety of 3-halospiro[4.5]trienones are readily prepared in good to excellent yields by the intramolecular ipso-halocyclization of 4-(p-methoxyaryl)-1-alkynes under mild reaction conditions. ICl, I2, and Br2 are all effective electrophiles for this process under carefully optimized reaction conditions.

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