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. 2005 Sep;112(9):1263-7.
doi: 10.1007/s00702-005-0338-9.

Untranslated region haplotype in dysbindin gene: analysis in schizophrenia

V De Luca  1 , D Voineskos, T Shinkai, G Wong, J L Kennedy
Affiliations

Untranslated region haplotype in dysbindin gene: analysis in schizophrenia

V De Luca et al. J Neural Transm (Vienna). 2005 Sep.

Abstract

Genome-scans performed in schizophrenia families have provided evidence for region 6p24-21 where variability may confer susceptibility to schizophrenia. Recent studies have implicated that gene DTNBP1 (dysbindin) in this region is strongly associated with schizophrenia. In a family based association study we investigated three markers located in the untranslated region of the DTNBP1 gene: rs909706, rs1047631 and rs742106. The sample size of our study is 117 families. No biased transmission towards the disorder was detected by haplotype analysis using TRANSMIT.

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