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. 2005 Sep 1:3:24.
doi: 10.1186/1476-7120-3-24.

What parameters affect left ventricular diastolic flow propagation velocity? In vitro studies using color M-mode Doppler echocardiography

Toshihiro Ogawa  1 , Lawrence N Scotten, David K Walker, Ajit P Yoganathan, Renee L Bess, Cheryl K Nordstrom, Julius M Gardin
Affiliations

What parameters affect left ventricular diastolic flow propagation velocity? In vitro studies using color M-mode Doppler echocardiography

Toshihiro Ogawa et al. Cardiovasc Ultrasound. .

Abstract

Background: Insufficient data describe the relationship of hemodynamic parameters to left ventricular (LV) diastolic flow propagation velocity (Vp) measured using color M-mode Doppler echocardiography.

Methods: An in vitro LV model used to simulate LV diastolic inflow with Vp measured under conditions of varying: 1) Stroke volume, 2) heart rate (HR), 3) LV volume, 4) LV compliance, and 5) transmitral flow (TMF) waveforms (Type 1: constant low diastasis flow and Type 2: no diastasis flow).

Results: Univariate analysis revealed excellent correlations of Vp with stroke volume (r = 0.98), LV compliance (r = 0.94), and HR with Type 1 TMF (r = 0.97). However, with Type 2 TMF, HR was not associated with Vp. LV volume was not related to Vp under low compliance, but inversely related to Vp under high compliance conditions (r = -0.56).

Conclusion: These in vitro findings may help elucidate the relationship of hemodynamic parameters to early diastolic LV filling.

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Figures

Figure 1
Figure 1
Type 1 transmitral flow velocity diagram: Constant diastasis flow. Heart rate = 60/min.
Figure 2
Figure 2
This graph shows a strong relationship between stroke volume (SV) and flow propagation velocity (Vp) (r = 0.98, p < 0.0001).
Figure 3
Figure 3
This graph shows an excellent correlation between LV compliance and Vp (r = 0.95, p < 0.0001).
Figure 4
Figure 4
Relationship between heart rate (HR) and Vp with a Type 1 transmitral flow pattern: There was a good correlation between HR and Vp (r = 0.97, p < 0.0001).
Figure 5
Figure 5
Relationship between heart rate (HR) and Vp with a Type 2 transmitral flow pattern: HR was not associated with Vp (r = 0.15, p = NS).
Figure 6
Figure 6
Relationship between LV volume (LVV) and Vp: Under low compliance conditions (no added air) and 70 ml stroke volume, LVV was not associated with Vp (r = 0.04, p = NS).
Figure 7
Figure 7
Relationship between LVV and Vp: Under low compliance conditions and 50 ml stroke volume, LVV was not associated with Vp (r = -0.08, p = NS).
Figure 8
Figure 8
Relationship between LVV and Vp: Under high compliance conditions (40 ml air in hydraulic chamber) and SV = 50 ml, LVV was inversely associated with Vp (r = -0.59, p < 0.0001).
Figure 9
Figure 9
Relationship between LVV and Vp: Under high compliance conditions and SV = 70 ml, LVV was inversely associated with Vp (r = -0.56, p < 0.0001).
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