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Comment
. 2005 Aug;9(4):327-8.
doi: 10.1186/cc3740. Epub 2005 Jun 2.

Renal blood flow in sepsis: a complex issue

Bruce A Molitoris  1
Affiliations
Comment

Renal blood flow in sepsis: a complex issue

Bruce A Molitoris. Crit Care. 2005 Aug.

Abstract

The clinical complexity of sepsis and the regional variability in renal blood flow present a difficult challenge for the clinician or investigator in understanding the role and clinical importance of reduced blood flow in the pathophysiology of sepsis-induced acute renal failure. Understanding the role of regional microvasculature flow and interactions between endothelium and white blood cells in the local delivery of oxygen and substrates is of critical importance. Therefore, measuring total renal blood flow may not permit an adequate understanding of the role of altered hemodynamics in septic patients who develop acute renal failure.

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Comment on

  • Renal blood flow in sepsis.
    Langenberg C, Bellomo R, May C, Wan L, Egi M, Morgera S. Langenberg C, et al. Crit Care. 2005 Aug;9(4):R363-74. doi: 10.1186/cc3540. Epub 2005 May 24. Crit Care. 2005. PMID: 16137349 Free PMC article. Review.

References

    1. Langenberg C, Bellomo R, May C, Wan L, Egi M, Morgera S. Renal blood flow in sepsis. Critical Care. 2005;9:R363–R374. doi: 10.1186/cc3540. - DOI - PMC - PubMed
    1. Angus DC, Linde-Zwirble WT, Lidicker J, Clermont G, Carcillo J, Pinsky MR. Epidemiology of severe sepsis in the United States: analysis of incidence, outcome, and associated costs of care. Crit Care Med . 2005;29:1303–1310. - PubMed
    1. Brun-Buisson C, Doyon F, Carlet J, Dellamonica P, Gouin F, Lepoutre A, Mercier JC, Offenstadt G, Regnier B. Incidence, risk factors, and outcome of severe sepsis and septic shock in adults. A multicenter prospective study in intensive care units. French ICU Group for Severe Sepsis. JAMA. 1995;274:968–974. doi: 10.1001/jama.274.12.968. - DOI - PubMed
    1. Rangel-Frausto MS, Pittet D, Costigan M, Hwang T, Davis CS, Wenzel RP. The natural history of the systemic inflammatory response syndrome (SIRS). A prospective study. JAMA. 1995;273:117–123. doi: 10.1001/jama.273.2.117. - DOI - PubMed
    1. Schor N. Acute renal failure and the sepsis syndrome. Kidney Int. 2002;61:764–776. doi: 10.1046/j.1523-1755.2002.00178.x. - DOI - PubMed