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. 2005 Sep 2;309(5740):1559-63.
doi: 10.1126/science.1112014.

The transcriptional landscape of the mammalian genome

P Carninci, T Kasukawa, S Katayama, J Gough, M C Frith, N Maeda, R Oyama, T Ravasi, B Lenhard, C Wells, R Kodzius, K Shimokawa, V B Bajic, S E Brenner, S Batalov, A R R Forrest, M Zavolan, M J Davis, L G Wilming, V Aidinis, J E Allen, A Ambesi-Impiombato, R Apweiler, R N Aturaliya, T L Bailey, M Bansal, L Baxter, K W Beisel, T Bersano, H Bono, A M Chalk, K P Chiu, V Choudhary, A Christoffels, D R Clutterbuck, M L Crowe, E Dalla, B P Dalrymple, B de Bono, G Della Gatta, D di Bernardo, T Down, P Engstrom, M Fagiolini, G Faulkner, C F Fletcher, T Fukushima, M Furuno, S Futaki, M Gariboldi, P Georgii-Hemming, T R Gingeras, T Gojobori, R E Green, S Gustincich, M Harbers, Y Hayashi, T K Hensch, N Hirokawa, D Hill, L Huminiecki, M Iacono, K Ikeo, A Iwama, T Ishikawa, M Jakt, A Kanapin, M Katoh, Y Kawasawa, J Kelso, H Kitamura, H Kitano, G Kollias, S P T Krishnan, A Kruger, S K Kummerfeld, I V Kurochkin, L F Lareau, D Lazarevic, L Lipovich, J Liu, S Liuni, S McWilliam, M Madan Babu, M Madera, L Marchionni, H Matsuda, S Matsuzawa, H Miki, F Mignone, S Miyake, K Morris, S Mottagui-Tabar, N Mulder, N Nakano, H Nakauchi, P Ng, R Nilsson, S Nishiguchi, S Nishikawa, F Nori, O Ohara, Y Okazaki, V Orlando, K C Pang, W J Pavan, G Pavesi, G Pesole, N Petrovsky, S Piazza, J Reed, J F Reid, B Z Ring, M Ringwald, B Rost, Y Ruan, S L Salzberg, A Sandelin, C Schneider, C Schönbach, K Sekiguchi, C A M Semple, S Seno, L Sessa, Y Sheng, Y Shibata, H Shimada, K Shimada, D Silva, B Sinclair, S Sperling, E Stupka, K Sugiura, R Sultana, Y Takenaka, K Taki, K Tammoja, S L Tan, S Tang, M S Taylor, J Tegner, S A Teichmann, H R Ueda, E van Nimwegen, R Verardo, C L Wei, K Yagi, H Yamanishi, E Zabarovsky, S Zhu, A Zimmer, W Hide, C Bult, S M Grimmond, R D Teasdale, E T Liu, V Brusic, J Quackenbush, C Wahlestedt, J S Mattick, D A Hume, C Kai, D Sasaki, Y Tomaru, S Fukuda, M Kanamori-Katayama, M Suzuki, J Aoki, T Arakawa, J Iida, K Imamura, M Itoh, T Kato, H Kawaji, N Kawagashira, T Kawashima, M Kojima, S Kondo, H Konno, K Nakano, N Ninomiya, T Nishio, M Okada, C Plessy, K Shibata, T Shiraki, S Suzuki, M Tagami, K Waki, A Watahiki, Y Okamura-Oho, H Suzuki, J Kawai, Y Hayashizaki; FANTOM Consortium; RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group)

The transcriptional landscape of the mammalian genome

P Carninci et al. Science. .

Erratum in

  • Science. 2006 Mar 24;311(5768):1713

Abstract

This study describes comprehensive polling of transcription start and termination sites and analysis of previously unidentified full-length complementary DNAs derived from the mouse genome. We identify the 5' and 3' boundaries of 181,047 transcripts with extensive variation in transcripts arising from alternative promoter usage, splicing, and polyadenylation. There are 16,247 new mouse protein-coding transcripts, including 5154 encoding previously unidentified proteins. Genomic mapping of the transcriptome reveals transcriptional forests, with overlapping transcription on both strands, separated by deserts in which few transcripts are observed. The data provide a comprehensive platform for the comparative analysis of mammalian transcriptional regulation in differentiation and development.

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Comment in

  • How many new genes are there?
    Lee LJ, Hughes TR, Frey BJ. Lee LJ, et al. Science. 2006 Mar 24;311(5768):1709-11; author reply 1709-11. doi: 10.1126/science.311.5768.1709b. Science. 2006. PMID: 16556823 No abstract available.

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