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. 2005 Jan;139(1):114-20.
doi: 10.1007/s10517-005-0227-0.

Characteristics of human neural stem cells in vitro and after transplantation into rat brain

M A Aleksandrova  1 , O V Podgornyi, M V Marei, R A Poltavtseva, E B Tsitrin, D V Gulyaev, L V Cherkasova, A V Revishchin, L I Korochkin, N G Khrushchov, G N Sukhikh
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Characteristics of human neural stem cells in vitro and after transplantation into rat brain

M A Aleksandrova et al. Bull Exp Biol Med. 2005 Jan.

Abstract

We studied the effect of culturing conditions on the fate of human neural stem cells after transplantation into rat brain. Human neural stem cells cultured in the presence of mitogens without LIF migrated along the ependyma and cerebral vessels of recipients, but to a great extent degenerated by the 20th day after transplantation. Neural stem cells cultured with LIF migrated, apart from the above mentioned pathways, in the cortex and hippocampus, well survived; proliferating cells were retained 30 days after transplantation.

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