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Review
. 2005 Sep 9;122(5):647-9.
doi: 10.1016/j.cell.2005.08.024.

"Bound" to work: the free hormone hypothesis revisited

John S Adams  1
Affiliations
Free article
Review

"Bound" to work: the free hormone hypothesis revisited

John S Adams. Cell. .
Free article

Abstract

Megalin is a member of the low-density lipoprotein receptor-related protein (LRP) family. The plasma membrane-anchored LRPs serve as receptors for a wide variety of extracellular ligands, promoting their entry into cells by endocytosis of the receptor-ligand complex. In this issue of Cell, Hammes et al. (2005) show that resistance (insensitivity) to sex steroid hormones is encountered in animals lacking megalin. These data provide important insights into an endocytic mechanism for the uptake of sex steroids by mammalian cells.

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Comment on

  • Role of endocytosis in cellular uptake of sex steroids.
    Hammes A, Andreassen TK, Spoelgen R, Raila J, Hubner N, Schulz H, Metzger J, Schweigert FJ, Luppa PB, Nykjaer A, Willnow TE. Hammes A, et al. Cell. 2005 Sep 9;122(5):751-62. doi: 10.1016/j.cell.2005.06.032. Cell. 2005. PMID: 16143106

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