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Review
. 2005 Nov 1;21(21):3943-50.
doi: 10.1093/bioinformatics/bti654. Epub 2005 Sep 6.

Computational methods for the design of effective therapies against drug resistant HIV strains

Niko Beerenwinkel  1 , Tobias Sing, Thomas Lengauer, Jörg Rahnenführer, Kirsten Roomp, Igor Savenkov, Roman Fischer, Daniel Hoffmann, Joachim Selbig, Klaus Korn, Hauke Walter, Thomas Berg, Patrick Braun, Gerd Fätkenheuer, Mark Oette, Jürgen Rockstroh, Bernd Kupfer, Rolf Kaiser, Martin Däumer
Affiliations
Review

Computational methods for the design of effective therapies against drug resistant HIV strains

Niko Beerenwinkel et al. Bioinformatics. .

Abstract

The development of drug resistance is a major obstacle to successful treatment of HIV infection. The extraordinary replication dynamics of HIV facilitates its escape from selective pressure exerted by the human immune system and by combination drug therapy. We have developed several computational methods whose combined use can support the design of optimal antiretroviral therapies based on viral genomic data.

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