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. 2005 Sep;43(9):4880-4.
doi: 10.1128/JCM.43.9.4880-4884.2005.

Direct application of the INNO-LiPA Rif.TB line-probe assay for rapid identification of Mycobacterium tuberculosis complex strains and detection of rifampin resistance in 360 smear-positive respiratory specimens from an area of high incidence of multidrug-resistant tuberculosis

Miguel Viveiros  1 , Clara Leandro, Liliana Rodrigues, Josefina Almeida, Rosário Bettencourt, Isabel Couto, Lurdes Carrilho, José Diogo, Ana Fonseca, Luís Lito, João Lopes, Teresa Pacheco, Mariana Pessanha, Judite Quirim, Luísa Sancho, Max Salfinger, Leonard Amaral
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Direct application of the INNO-LiPA Rif.TB line-probe assay for rapid identification of Mycobacterium tuberculosis complex strains and detection of rifampin resistance in 360 smear-positive respiratory specimens from an area of high incidence of multidrug-resistant tuberculosis

Miguel Viveiros et al. J Clin Microbiol. 2005 Sep.

Abstract

The INNO-LiPA Rif.TB assay for the identification of Mycobacterium tuberculosis complex strains and the detection of rifampin (RIF) resistance has been evaluated with 360 smear-positive respiratory specimens from an area of high incidence of multidrug-resistant tuberculosis (MDR-TB). The sensitivity when compared to conventional identification/culture methods was 82.2%, and the specificity was 66.7%; the sensitivity and specificity were 100.0% and 96.9%, respectively, for the detection of RIF resistance. This assay has the potential to provide rapid information that is essential for the effective management of MDR-TB.

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Figures

FIG. 1.
FIG. 1.
TB Fast Track work algorithm. IHMT, Instituto de Higiene e Medicina Tropical; aver., average.
See this image and copyright information in PMC

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