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. 2005 Aug;77(2):330-2.
doi: 10.1086/432422.

LRRK2 haplotype analyses in European and North African families with Parkinson disease: a common founder for the G2019S mutation dating from the 13th century

Suzanne Lesage, Anne-Louise Leutenegger, Pablo Ibanez, Sabine Janin, Ebba Lohmann, Alexandra Dürr, Alexis Brice; French Parkinson's Disease Genetics Study Group

LRRK2 haplotype analyses in European and North African families with Parkinson disease: a common founder for the G2019S mutation dating from the 13th century

Suzanne Lesage et al. Am J Hum Genet. 2005 Aug.
No abstract available

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Figures

Figure 1
Figure 1
Genotypes for chromosome 12q12 markers in the disease haplotype in subjects from 14 LRRK2-positive families. The sequences of the microsatellites and SNPs were from the GDB Human Genome Database and Entrez SNP, respectively. An asterisk (*) indicates an unaffected individual from the control population who carried the G2019S mutation. A double asterisk (**) indicates a homozygous G2019S carrier. For families in which phase could not be unambiguously determined, both alleles are shown. The haplotype shared by all G2019S carriers is highlighted in gray.
See this image and copyright information in PMC

References

Web Resources

    1. Center for Statistical Genetics, http://www.sph.umich.edu/csg/abecasis/Merlin/
    1. Entrez SNP, http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?CMD=search&DB=snp
    1. GDB Human Genome Database, http://www.gdb.org/
    1. Genbank, http://www.ncbi.nlm.nih.gov/Genbank/ (for Homo sapiens LRRK2 [accession number AY792511])
    1. Online Mendelian Inheritance in Man (OMIM), http://www.ncbi.nlm.nih.gov/Omim/ (for PD) - PubMed

References

    1. Abecasis GR, Cherny SS, Cookson WO, Cardon LR (2002) Merlin—rapid analysis of dense genetic maps using sparse gene flow trees. Nat Genet 30:97–10110.1038/ng786 - DOI - PubMed
    1. Di Fonzo A, Rohe CF, Ferreira J, Chien HF, Vacca L, Stocchi F, Guedes L, Fabrizio E, Manfredi M, Vanacore N, Goldwurm S, Breedveld G, Sampaio C, Meco G, Barbosa E, Oostra BA, Bonifati V, Italian Parkinson Genetics Network (2005) A frequent LRRK2 gene mutation associated with autosomal dominant Parkinson’s disease. Lancet 365:412–415 - PubMed
    1. Excoffier L, Slatkin M (1995) Maximum-likelihood estimation of molecular haplotype frequencies in a diploid population. Mol Biol Evol 12:921–927 - PubMed
    1. Genin E, Tullio-Pelet A, Begeot F, Lyonnet S, Abel L (2004) Estimating the age of rare disease mutations: the example of triple-A syndrome. J Med Genet 41:445–44910.1136/jmg.2003.017962 - DOI - PMC - PubMed
    1. Gilks WP, Abou-Sleiman PM, Gandhi S, Jain S, Singleton A, Lees AJ, Shaw K, Bhatia KP, Bonifati V, Quinn NP, Lynch J, Healy DG, Holton JL, Revesz T, Wood NW (2005) A common LRRK2 mutation in idiopathic Parkinson’s disease. Lancet 365:415–416 - PubMed

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