Review
doi: 10.1111/j.1753-4887.1992.tb01298.x.
Buthionine sulfoximine, an experimental tool to induce glutathione deficiency: elucidation of glutathione and ascorbate in their role as antioxidants
Affiliations
- PMID: 1614638
- DOI: 10.1111/j.1753-4887.1992.tb01298.x
Item in Clipboard
Review
Buthionine sulfoximine, an experimental tool to induce glutathione deficiency: elucidation of glutathione and ascorbate in their role as antioxidants
Nutr Rev.
1992 Apr.
Abstract
The development of buthionine sulfoximine, a selective inhibitor of glutathione biosynthesis, is an important new tool to elucidate the in vivo role of glutathione. Recent investigations have shown that ascorbic acid can serve as an essential antioxidant in the presence of severe glutathione deficiency.
Similar articles
-
Glutathione deficiency decreases tissue ascorbate levels in newborn rats: ascorbate spares glutathione and protects.Proc Natl Acad Sci U S A. 1991 Jun 1;88(11):4656-60. doi: 10.1073/pnas.88.11.4656. Proc Natl Acad Sci U S A. 1991. PMID: 2052548 Free PMC article.
-
Stereospecific effects of R-lipoic acid on buthionine sulfoximine-induced cataract formation in newborn rats.Biochem Biophys Res Commun. 1996 Apr 16;221(2):422-9. doi: 10.1006/bbrc.1996.0611. Biochem Biophys Res Commun. 1996. PMID: 8619871
-
Depletion of glutathione in normal and malignant human cells in vivo by L-buthionine sulfoximine: possible interaction with ascorbate.J Natl Cancer Inst. 1992 Oct 21;84(20):1601-2. doi: 10.1093/jnci/84.20.1601-a. J Natl Cancer Inst. 1992. PMID: 1285780 No abstract available.
-
Mitochondrial changes associated with glutathione deficiency.Biochim Biophys Acta. 1995 May 24;1271(1):35-42. doi: 10.1016/0925-4439(95)00007-q. Biochim Biophys Acta. 1995. PMID: 7599223 Review.
-
Guarding against cellular glutathione deficiency.Nutr Rev. 1990 Sep;48(9):346-8. doi: 10.1111/j.1753-4887.1990.tb02978.x. Nutr Rev. 1990. PMID: 2096333 Review. No abstract available.
Cited by
-
N-Acetylcysteine and Aripiprazole Improve Social Behavior and Cognition and Modulate Brain BDNF Levels in a Rat Model of Schizophrenia.Int J Mol Sci. 2022 Feb 15;23(4):2125. doi: 10.3390/ijms23042125. Int J Mol Sci. 2022. PMID: 35216241 Free PMC article.
-
No evident dose-response relationship between cellular ROS level and its cytotoxicity--a paradoxical issue in ROS-based cancer therapy.Sci Rep. 2014 May 22;4:5029. doi: 10.1038/srep05029. Sci Rep. 2014. PMID: 24848642 Free PMC article. Clinical Trial.
-
Anti-tumour and anti-oxidative potential of diosgenin against 7, 12-dimethylbenz(a)anthracene induced experimental oral carcinogenesis.Pathol Oncol Res. 2012 Apr;18(2):405-12. doi: 10.1007/s12253-011-9460-1. Epub 2011 Oct 12. Pathol Oncol Res. 2012. PMID: 21990007
-
Copper-Catalyzed Click Reaction on/in Live Cells.Chem Sci. 2017 Mar 1;8(3):2107-2114. doi: 10.1039/C6SC02297A. Epub 2016 Nov 25. Chem Sci. 2017. PMID: 28348729 Free PMC article.
-
Glutathione Deficiency during Early Postnatal Development Causes Schizophrenia-Like Symptoms and a Reduction in BDNF Levels in the Cortex and Hippocampus of Adult Sprague-Dawley Rats.Int J Mol Sci. 2021 Jun 8;22(12):6171. doi: 10.3390/ijms22126171. Int J Mol Sci. 2021. PMID: 34201038 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Medical
