Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2005 Oct;5(5):322-32.
doi: 10.1016/j.mito.2005.06.005.

Mitochondrial regulation of oxygen sensing

Eric L Bell  1 , Brooke M Emerling, Navdeep S Chandel
Affiliations
Review

Mitochondrial regulation of oxygen sensing

Eric L Bell et al. Mitochondrion. 2005 Oct.

Abstract

Maintenance of oxygen homoeostasis is required for the survival of higher organisms. The transcription factor hypoxia inducible factor (HIF) has a crucial role in oxygen homoeostasis by integrating the decrease in oxygen levels to increase hypoxic gene expression. How cells sense decrease in oxygen levels to elicit an increase in HIF dependent gene expression is not fully understood. In this review, we discuss the role of mitochondria as oxygen sensors regulating HIF.

PubMed Disclaimer

Publication types

LinkOut - more resources