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. 2005 Sep 29;360(1461):1645-6.
doi: 10.1098/rstb.2005.1731.

Foxp3 and dominant tolerance

Alexander Rudensky  1
Affiliations

Foxp3 and dominant tolerance

Alexander Rudensky. Philos Trans R Soc Lond B Biol Sci. .
No abstract available

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Figures

Figure 1
Figure 1
T lymphocytes develop the regulatory phenotype of dominant tolerance due to their expression of the gene Foxp3. (a) Scanning electron micrograph of a T lymphocyte; (b) Foxp3-gfp gene construct (Fontenot et al. 2005) encoding both Foxp3 protein and green fluorescent protein; (c) introduction of the Foxp3-gfp gene construct into the mouse genome has enabled direct visualization of regulatory T lymphocytes within the thymus, revealed as individual fluorescent green cells alongside a blood vessel.
See this image and copyright information in PMC

References

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    1. Fontenot J.D, Gavin M.A, Rudensky A.Y. Foxp3 programs the development and function of CD4+CD25+ regulatory T cells. Nat. Immunol. 2003;4:330–336. doi:10.1038/ni904 - DOI - PubMed
    1. Fontenot J.D, Rasmussen J.P, Williams L.M, Dooley J.L, Farr A.G, Rudensky A.Y. Regulatory T cell lineage specification by the forkhead transcription factor foxp3. Immunity. 2005;22:329–341. doi:10.1016/j.immuni.2005.01.016 - DOI - PubMed

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