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Review
. 2005 Sep 29;360(1461):1707-11.
doi: 10.1098/rstb.2005.1702.

CAMPATH: from concept to clinic

Herman Waldmann  1 , Geoff Hale
Affiliations
Review

CAMPATH: from concept to clinic

Herman Waldmann et al. Philos Trans R Soc Lond B Biol Sci. .

Abstract

Lymphocyte depletion has a long history in the area of therapeutic immunosuppression. CAMPATH-1H (alemtuzumab) was generated in an attempt to replace anti-lymphocyte globulins in the transplant arena. Its efficacy in killing lymphocytes has established it as a licensed drug for the management of chronic lymphocyte leukaemia. Short-term therapy with alemtuzumab has demonstrated long-term benefit in a number of autoimmune conditions. This drug has the potential to facilitate recruitment of tolerance processes so enabling drug minimization in transplantation, autoimmune and hypersensitivity diseases.

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References

    1. Axelrod D, Leventhal J.R, Gallon L.G, Parker M.A, Kaufman D.B. Reduction of CMV disease with steroid-free immunosuppresssion in simultaneous pancreas-kidney transplant recipients. Am. J. Transplant. 2005;5:1423–1429. - PubMed
    1. Bruggemann M, Free J, Diamond A, Howard J, Cobbold S, Waldmann H. Immunoglobulin heavy chain locus of the rat: striking homology to mouse antibody genes. Proc. Natl Acad. Sci. USA. 1986;83:6075–6079. - PMC - PubMed
    1. Bruggemann M, Williams G.T, Bindon C.I, Clark M.R, Walker M.R, Jefferis R, Waldmann H, Neuberger M.S. Comparison of the effector functions of human immunoglobulins using a matched set of chimeric antibodies. J. Exp. Med. 1987;166:1351–1361. - PMC - PubMed
    1. Bruggemann M, Winter G, Waldmann H, Neuberger M.S. The immunogenicity of chimeric antibodies. J. Exp. Med. 1989;170:2153–2157. - PMC - PubMed
    1. Calne R, et al. Campath IH allows low-dose cyclosporine monotherapy in 31 cadaveric renal allograft recipients. Transplantation. 1999;68:1613–1616. - PubMed

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