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Review
. 2005 Nov 1;96(4):682-8.
doi: 10.1002/jcb.20589.

Advances in understanding bone cancer pain

M J Goblirsch  1 , P Zwolak, D R Clohisy
Affiliations
Review

Advances in understanding bone cancer pain

M J Goblirsch et al. J Cell Biochem. .

Abstract

Experimental animal models of bone cancer pain have emerged and findings have provided a unique glimpse into unraveling the mechanism that drives this debilitating condition. Key contributors to the generation and maintenance of bone cancer pain are tumor-induced osteolysis, tumor itself, and production of nociceptive mediators in the bone-tumor microenvironment.

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