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. 2005 Sep 14;11(34):5322-6.
doi: 10.3748/wjg.v11.i34.5322.

Limited influences of chemotherapy on healthy and metastatic liver parenchyma

Nancy Van Damme  1 , Pieter Demetter, Wouter De Bock, Marianne Rottiers, Marleen Praet, Bernard de Hemptinne, Marc Peeters
Affiliations

Limited influences of chemotherapy on healthy and metastatic liver parenchyma

Nancy Van Damme et al. World J Gastroenterol. .

Abstract

Aim: To examine the expression of E-cadherin, beta-catenin, gamma-catenin, VEGF, and p53 in 39 patients with hepatic metastasis from colorectal cancer immunohistochemically.

Methods: The patients were divided into two groups: those (n = 16) who had no chemotherapy for at least 6 mo before the liver resections and those (n = 23) who were treated with chemotherapy before liver resections. A score from 0 to 3 was given for the number of positive cells and from 0 to 3 for the intensity of staining in these cells, in both healthy and metastatic liver parenchyma.

Results: No significant differences in the expression of E-cadherin, beta- and gamma-catenin, VEGF and p53, could be observed between patients who received and did not receive chemotherapy, in both normal and metastatic liver parenchyma.

Conclusion: Despite the assumption that chemotherapy had an effect on liver metastasis, no influences were noticed immunohistochemically.

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Figures

Figure 1
Figure 1
E-cadherin expression in a liver metastasis. Magnification x40.
Figure 2
Figure 2
VEGF expression in a liver metastasis. Magnification x40.
Figure 3
Figure 3
p53 expression in a liver metastasis. Magnification x40.
See this image and copyright information in PMC

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