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. 2006 Jan 15;102(1):67-73.
doi: 10.1016/j.imlet.2005.07.006. Epub 2005 Aug 2.

Role of ADAM8 in experimental asthma

Osamu Matsuno  1 , Eishi Miyazaki, Shinichi Nureki, Takuya Ueno, Toshihide Kumamoto, Yasunori Higuchi
Affiliations

Role of ADAM8 in experimental asthma

Osamu Matsuno et al. Immunol Lett. .

Abstract

A disintegrin and metalloprotease (ADAM) family members, characterized by a metalloprotease and a disintegrin domain, are membrane-anchored glycoproteins involved in proteolysis and cell adhesion. ADAM8 is specifically induced in the experimental murine asthmatic lung. To evaluate novel pathways involved in asthma pathogenesis, using ADAM8 transgenic mice (ATMS2) in a murine model of asthma. Massive cellular infiltrates in peribronchovascular and interstitial lesions were observed in control mice, while in ATMS2 mice there were only occasional. Vascular cell adhesion molecule (VCAM-1) is involved in specific eosinophil adhesions via alpha4beta1 integrin. VCAM-1 shedding was mediated by the ADAM8 metalloprotease. Endothelial cell shedding of VCAM-1 was increased in ATMS2-stimulated human umbilical endothelial cells. ADAM8-mediated shedding of VCAM-1 might be important for the suppression of experimental asthma. Our data suggest that ADAM8 is a useful therapeutic target.

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