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Review
. 2006 Aug 8;239(2):157-67.
doi: 10.1016/j.canlet.2005.07.029. Epub 2005 Sep 9.

Polycyclic aromatic hydrocarbon-DNA adduct formation in prostate carcinogenesis

Benjamin A Rybicki  1 , Nora L Nock, Adnan T Savera, Deliang Tang, Andrew Rundle
Affiliations
Review

Polycyclic aromatic hydrocarbon-DNA adduct formation in prostate carcinogenesis

Benjamin A Rybicki et al. Cancer Lett. .

Abstract

The evidence for polycyclic aromatic hydrocarbons (PAH) playing a role in prostate carcinogenesis comes mainly from associations between reported PAH exposures and prostate cancer in epidemiologic studies. Associations between prostate cancer and DNA repair genotypes and phenotypes have also been reported, lending further credence to a PAH-induced carcinogenesis pathway in prostate cancer. Recent work that demonstrates the human prostate has metabolic enzyme activity necessary for PAH activation and will form DNA adducts upon exposure to PAH further supports PAH carcinogenesis. We have demonstrated the presence of PAH-DNA adducts in prostate cancer cases, but further validation of this biomarker as a carcinogenic agent in human prostate is needed.

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Figures

Fig. 1
Fig. 1
Enzymatic conversion pathways of benzo[a]pyrene catalyzed by cytochrome P450s (P450s) and the aldo-keto reductase 1C (AKR1C) into activated compounds BPQ and BPDE that can bind with the 2-amino group of deoxyguanosine to form DNA adducts. Also depicted is the detoxification pathway catalyzed by glutathione-S-transferases (GSTs).
Fig. 2
Fig. 2
(a) 5D11 monoclonal antibody staining of epithelial prostate normal and tumor cells in a tissue section removed from a prostatectomy sample. (b) 5D11 monoclonal antibody staining of epithelial prostate normal cells in a tissue section removed from a needle prostate biopsy of a patient without prostate cancer.
See this image and copyright information in PMC

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