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Review
. 2005 Dec 9;338(1):610-6.
doi: 10.1016/j.bbrc.2005.08.193. Epub 2005 Sep 2.

Regulation of hypoxia-inducible factor 1 by prolyl and asparaginyl hydroxylases

Kiichi Hirota  1 , Gregg L Semenza
Affiliations
Review

Regulation of hypoxia-inducible factor 1 by prolyl and asparaginyl hydroxylases

Kiichi Hirota et al. Biochem Biophys Res Commun. .

Abstract

Hypoxia-inducible factor 1 (HIF-1) functions as a master regulator of oxygen homeostasis by mediating a wide range of cellular and systemic adaptive physiological responses to reduced oxygen availability. In this review, we will summarize recent progress in elucidating the molecular mechanisms of HIF-1 activation, focusing on the role of oxygen-dependent prolyl and asparaginyl hydroxylases in hypoxia signal transduction.

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