New 24-membered macrolides SPA-6952A and B produced by Streptomyces sp
- PMID: 16156518
- DOI: 10.1038/ja.2005.52
New 24-membered macrolides SPA-6952A and B produced by Streptomyces sp
Abstract
Two new 24-membered macrolides, SPA-6952A and B, were isolated from the fermentation broth of Streptomyces sp. SPA-6952. The structures of the new macrolides were determined by spectral analyses, including 2D NMR techniques. These compounds exhibited cytotoxic activity against human promyelocytic leukemia HL-60 cells.
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