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. 2005;12(3):112-4.
doi: 10.1258/0969141054855300.

Neonatal screening for sickle cell disorders in Ouagadougou, Burkina Faso: a pilot study

Eléonore Kafando  1 , Mamadou Sawadogo, Frédéric Cotton, Fanchon Vertongen, Béatrice Gulbis
Affiliations

Neonatal screening for sickle cell disorders in Ouagadougou, Burkina Faso: a pilot study

Eléonore Kafando et al. J Med Screen. 2005.

Abstract

Objectives: To determine the incidence of sickle cell disorders (SCDs) and the feasibility of a neonatal screening programme in Ouagadougou.

Methods: During 2000, 2003 and 2004, 2341 cord blood samples obtained in five maternity hospitals in Ouagadougou were screened for SCDs using an isoelectric focusing technique. The feasibility of a neonatal screening programme was evaluated.

Results: The incidence of SCD was 1:57; 14 neonates were homozygous for haemoglobin (Hb)S and 27 were compound heterozygotes for HbSC. Thirty-two neonates were homozygous for HbC. The incidence of the HbC trait was 1:6; incidence of the HbS trait was 1:14. A centralized laboratory for neonatal screening of SCDs was established.

Conclusions: SCDs should be considered a major public health problem in Ouagadougou. A neonatal screening programme should be implemented, but to be effective it requires strategies adapted to the local situation.

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