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. 2005 Nov;196(1):204-8.
doi: 10.1016/j.expneurol.2005.07.024. Epub 2005 Sep 12.

TNF-alpha antibody infusion impairs survival of stroke-generated neuroblasts in adult rat brain

Ursula Heldmann  1 , Pär Thored, Jan-Hendrik Claasen, Andreas Arvidsson, Zaal Kokaia, Olle Lindvall
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TNF-alpha antibody infusion impairs survival of stroke-generated neuroblasts in adult rat brain

Ursula Heldmann et al. Exp Neurol. 2005 Nov.

Abstract

Stroke induced by 2 h middle cerebral artery occlusion triggers increased striatal and hippocampal neurogenesis in adult rats. We investigated the effect of tumor necrosis factor-alpha (TNF-alpha) inhibition on the survival of the new neurons. The mitotic marker BrdU was given on days 5 to 7, and TNF-alpha antibody or control protein was infused into the lateral ventricle of the ischemic hemisphere from day 8 to 14 after stroke. At the end of infusions, the TNF-alpha antibody-treated rats showed markedly fewer new striatal and hippocampal neurons, as compared to animals given control protein. The present findings suggest that TNF-alpha, probably acting via its receptor TNFR2, can promote the survival of stroke-generated hippocampal and striatal neurons.

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