Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2005 Sep 13;65(5):745-7.
doi: 10.1212/01.wnl.0000174432.87383.87.

Regional cortical thinning in preclinical Huntington disease and its relationship to cognition

H D Rosas  1 , N D Hevelone, A K Zaleta, D N Greve, D H Salat, B Fischl
Affiliations

Regional cortical thinning in preclinical Huntington disease and its relationship to cognition

H D Rosas et al. Neurology. .

Abstract

The authors studied presymptomatic individuals with the Huntington disease (HD) mutation to determine whether cortical thinning was present. They found thinning that was regionally selective, semi-independent of striatal volume loss, and correlated with cognitive performance. Early, extensive cortical involvement occurs during the preclinical stages of HD.

PubMed Disclaimer

Publication types

MeSH terms