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Case Reports
. 2005 Sep 13;65(5):762-4.
doi: 10.1212/01.wnl.0000174517.21383.36.

Lamotrigine associated with exacerbation or de novo myoclonus in idiopathic generalized epilepsies

A Crespel  1 , P Genton, M Berramdane, P Coubes, C Monicard, M Baldy-Moulinier, P Gelisse
Affiliations
Case Reports

Lamotrigine associated with exacerbation or de novo myoclonus in idiopathic generalized epilepsies

A Crespel et al. Neurology. .

Abstract

Five patients with idiopathic generalized epilepsies (IGE) treated with lamotrigine (LTG) experienced exacerbation or de novo appearance of myoclonic jerks (MJ). In three patients, LTG exacerbated MJ in a dose-dependent manner with early aggravation during titration. MJ disappeared when LTG dose was decreased by 25 to 50%. In two patients, LTG exacerbated MJ in a delayed but more severe manner, with myoclonic status that only ceased after LTG withdrawal.

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