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Comparative Study
. 2005 Oct;8(10):1289-91.
doi: 10.1038/nn1548. Epub 2005 Sep 11.

Agouti-related peptide-expressing neurons are mandatory for feeding

Eva Gropp  1 , Marya Shanabrough, Erzsebet Borok, Allison W Xu, Ruth Janoschek, Thorsten Buch, Leona Plum, Nina Balthasar, Brigitte Hampel, Ari Waisman, Gregory S Barsh, Tamas L Horvath, Jens C Brüning
Affiliations
Comparative Study

Agouti-related peptide-expressing neurons are mandatory for feeding

Eva Gropp et al. Nat Neurosci. 2005 Oct.

Abstract

Multiple hormones controlling energy homeostasis regulate the expression of neuropeptide Y (NPY) and agouti-related peptide (AgRP) in the arcuate nucleus of the hypothalamus. Nevertheless, inactivation of the genes encoding NPY and/or AgRP has no impact on food intake in mice. Here we demonstrate that induced selective ablation of AgRP-expressing neurons in adult mice results in acute reduction of feeding, demonstrating direct evidence for a critical role of these neurons in the regulation of energy homeostasis.

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