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Review
. 2005 Jun;81(5):433-6.
doi: 10.1532/ijh97.04187.

Rituximab provided long-term remission in a patient with refractory relapsing thrombotic thrombocytopenic purpura

Satoru Kosugi  1 , Masanori Matsumoto, Yasushi Ohtani, Hironori Take, Hiromichi Ishizashi, Yoshihiro Fujimura, Jun Kuyama
Affiliations
Review

Rituximab provided long-term remission in a patient with refractory relapsing thrombotic thrombocytopenic purpura

Satoru Kosugi et al. Int J Hematol. 2005 Jun.

Abstract

We describe a 69-year-old man with refractory relapsing thrombotic thrombocytopenic purpura (TTP) successfully treated with rituximab. The patient had once been successfully treated with plasmapheresis and vincristine, but he had relapsed after a short period. Although plasmapheresis, vincristine, and splenectomy could not achieve a consistent elevation of the platelet count, rituximab administration provided sustained remission for more than 7 months. Rituximab should be considered as a therapeutic alternative for refractory TTP.

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