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Review
. 2005 Oct;79(19):12125-31.
doi: 10.1128/JVI.79.19.12125-12131.2005.

Adenovirus receptors

Yuanming Zhang  1 , Jeffrey M Bergelson
Affiliations
Review

Adenovirus receptors

Yuanming Zhang et al. J Virol. 2005 Oct.
No abstract available

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Figures

FIG. 1.
FIG. 1.
Adenovirus structure. (A) Virion structure at 17-Å resolution. Each of the 20 triangular faces of the capsid is composed of 12 copies of the hexon trimer (blue). At each fivefold vertex, a fiber (green) emerges from the pentameric penton base (yellow). The hexon capsid and penton base structures are derived from a cryoelectron microscopic image reconstruction of human adenovirus 5. Fibers are modeled from the atomic structure of the Ad2 fiber (95). Figure provided by Carmen San Martin. (B) Penton base. Side and top views, showing flexible RGD loops projecting from the surface. The insertion sites for fiber are also shown. (The figure is reprinted from reference with permission of the publisher.) (C) Fiber structure and receptor binding sites. The fiber is a trimer whose monomers are indicated in red, blue, and green; the shaft is a tightly wound triple spiral; the knob is a more bulbous trefoil. The figure is modified from reference with permission of the publisher.
FIG. 2.
FIG. 2.
Geometric constraints on receptor interaction. In panels A and B, attachment of a short fiber (green) to CAR on the cell surface does not permit the penton base protein to interact with a cell surface integrin molecule. In panel C, a virus with a long flexible fiber is able to interact with CAR and integrin at the same time. The figure is modified from Wu et al. (101) with permission.
See this image and copyright information in PMC

References

    1. Albinsson, B., and A. H. Kidd. 1999. Adenovirus type 41 lacks an RGD αv-integrin binding motif on the penton base and undergoes delayed uptake in A549 cells. Virus Res. 64:125-136. - PubMed
    1. Alemany, R., and D. T. Curiel. 2001. CAR-binding ablation does not change biodistribution and toxicity of adenoviral vectors. Gene Ther. 8:1347-1353. - PubMed
    1. Arnberg, N., K. Edlund, A. H. Kidd, and G. Wadell. 2000. Adenovirus type 37 uses sialic acid as a cellular receptor. J. Virol. 74:42-48. - PMC - PubMed
    1. Arnberg, N., A. H. Kidd, K. Edlund, F. Olfat, and G. Wadell. 2000. Initial interactions of subgenus D adenoviruses with A549 cellular receptors: sialic acid versus αv integrins. J. Virol. 74:7691-7693. - PMC - PubMed
    1. Arnberg, N., P. Pring-Akerblom, and G. Wadell. 2002. Adenovirus type 37 uses sialic acid as a cellular receptor on Chang C cells. J. Virol. 76:8834-8841. - PMC - PubMed

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