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. 2005 Oct;24(7):801-3.
doi: 10.1097/01.ico.0000157407.43699.22.

Trends in the indications for penetrating keratoplasty, 1980-2001

Paul C Kang  1 , Gordon K Klintworth, Terry Kim, Alan N Carlson, Ron Adelman, Sandra Stinnett, Natalie A Afshari
Affiliations

Trends in the indications for penetrating keratoplasty, 1980-2001

Paul C Kang et al. Cornea. 2005 Oct.

Abstract

Purpose: To study the leading indications and changing trends for penetrating keratoplasty (PK) over the past 3 decades.

Methods: This is a retrospective review of 696 cases of PK. The indications for PKs performed at the Duke University Eye Center during the years 1980-1981, 1990- 1991, and 2000-2001 were tabulated to determine trends over the past 3 decades. The main outcome measures were indications for PK.

Results: During this study, 696 PKs were performed. The leading indications for PK and their respective frequencies during 1980-1981, 1990-1991, and 2000-2001 were failed grafts (10.8%, 19.0%, 27.0%, respectively), pseudophakic bullous keratopathy (PBK)/aphakic bullous keratopathy (ABK) (19.4%, 20.6%, 16.7%, respectively), Fuchs dystrophy (15.6%, 13.0%, 23.8%, respectively), keratoconus (13.4%, 8.2%, 11.8%, respectively), and corneal scar (7.0%, 8.9%, 10.7%, respectively). The number of PKs for failed grafts and Fuchs dystrophy increased over time.

Conclusions: In this study, failed graft has gradually become the leading indication for PK, whereas most other studies have reported PBK as the leading indication. Unlike many other studies, Fuchs dystrophy was a common indication for PK.

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